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Genetic make-up has little impact on dental health

Lead researcher states that it’s important that people don’t link tooth decay to genetic make-up, so that they are prepared to make important lifestyle changes to prevent it
by TR Pakistan

A new study has found genetic makeup does not predispose people to tooth decay, however, the research did find that children with overweight mothers are more likely to have cavities.

The paper, published in a latest edition of the international journal Pediatrics, estimates that one in three Australian children have tooth decay by the time they start school.

Lead researcher Dr. Mihiri J. Silva, from the Murdoch Children’s Research Institute, said the study looked at the teeth of 173 sets of twins (identical and non-identical) from pregnancy through to six years of age.

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Questionnaires about the mother’s weight, illnesses, medication use, vitamin D levels, stress, alcohol intake and smoking were collected during pregnancy. The study collected data about the twins at 24- and 36-week gestational age, birth, as well as at 18-months and six years of age. This also included an examination for dental caries and enamel defects at age six.

“How genetics impact dental health has not often been studied,” said Dr. Silva in a press release by the University of Melbourne. “This is the first twin study that looks at both genetics and early life risk factors, such as illness and lifestyle.

“We found that identical twins, with identical genomes, have varying degrees of decay. This means that environmental factors, like a lack of fluoride in water, seem to be the prime cause of cavities not genetic makeup.”

However, the research did find a link between the mother’s health and lifestyle during pregnancy and the child’s future dental health, with obesity in pregnancy a definite marker for increased risk of child tooth decay.

The relationship between maternal obesity and child tooth decay is complex. Perhaps the mother’s weight has a biological influence on the developing fetus or perhaps the risk of decay rises because of increased sugar consumption in that household.

The study found that one in three of the twins studied (32.2 percent) had dental decay, and almost one in four (24.1 percent) had advanced decay.

Dr. Silva noted  it was important that people don’t think of tooth decay as genetic. “If people think the health of their teeth is down to their genetic make-up, they may not be prepared to make important lifestyle changes,” she said.

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The researchers stated that their findings reinforce how important it is for pediatricians and other health professionals to educate children to start preventive measures early in life, prior to the onset of damage to dental tissues.

Tooth decay is a serious health problem, because there was a clear link between child cavities and developing diabetes and cardiovascular disease later in life.

According to 2011 Victorian Department of Health statistics, more than 26,000 Australians under the age of 15 are admitted to hospital to treat tooth decay every year.

Dr. Katrina Scurrah, from Twins Research Australia and the School of Population and Global Health at the University of Melbourne, said the study illustrated the advantages of studying twins to find out about health conditions and the importance of considering the effects of early life risk factors as well as genes.

Though it is important to try to replicate these findings in other studies that follow children through to adulthood and to explore other risk factors for dental decay, she added.


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