Nanochemistry Laboratory of the Government College University has got a United States patent on “Drug entrapment efficiency and sustained drug release of Chloramphenicol loaded polymeric-iron nanoparticles” in the field of applied research.
The patent in the field of nanotechnology is the result of research done by the group of scientists under the supervision of Dr Muhammad Akhyar Farrukh.
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. It is a bacteriostatic. The original indication of chloramphenicol was in the treatment of typhoid fever, treatment of tetracycline-resistant cholera.
The formulation of chloramphenicol loaded polymeric-iron composite with the nano-size increases its activity for the treatment of infections. This research work yields nanocomposite which enable targeted delivery of antibiotic. Biodegradable and biocompatible polymer such as diethylaminoethyl-cellulose (DEAE-Cellulose) was used in combination with iron, which contributes its magnetic characteristics to the nanocomposite. Antibacterial activity of chloramphenicol loaded polymeric-iron nanocomposite was found more extensive than the commercially available chloramphenicol eye drops and showed a maximum of drug entrapment efficiency (DEE) in 48 h exhibiting sustained release of drug. This research work harvests nanocomposite which enable sustained release and targeted delivery of antibiotics as well as to cover deficiency of iron.
Iron nanoparticles of magnetic nature are suitable candidates for sustained and/or prolonged drug delivery. Iron magnetic nanoparticles loaded with drug enhances the effect of drug tremendously in drug delivery.
Chloramphenicol is used for treatment of eye and ear infections and typhoid fever, but this drug has poor bioavailability when given orally due to its poor solubility in the gastrointestinal tract and its early degradation.
These issues can be solved by giving Chloramphenicol loaded polymeric-iron drug orally which is produced by the scientists of Nanochemistry Lab, GC University Lahore, Pakistan.